Cell cycle regulation, neurogenesis, and depression
نویسندگان
چکیده
منابع مشابه
Cell cycle regulation, neurogenesis, and depression.
T he mammalian brain was originally thought to birth new neurons only during development. A modern paradigm shift began in the 1960s as experimental evidence of neurogenesis in adult brain and its functional implications began to emerge. Neural stem cells have now been identified to undergo mitosis, proliferate, and differentiate into neurons, astroglia, or oligodendroglia within specialized ne...
متن کاملCell cycle regulation during mouse olfactory neurogenesis.
The development of the nervous system requires a strict control of cell cycle entry and withdrawal. The olfactory epithelium (OE) is noticeable by its ability to yield new neurons not only during development but also continuously during adulthood. The aim of our study was to investigate, by biochemical and immunohistochemical methods, which cell cycle regulators are involved in the control of n...
متن کاملNeurogenesis and the Cell Cycle
For a long time, it has been understood that neurogenesis is linked to proliferation and thus to the cell cycle. Recently, the gears that mediate this linkage have become accessible to molecular investigation. This review describes some of the progress that has been made in understanding how the molecular machinery of the cell cycle is used in the processes of size regulation in the brain, hist...
متن کاملSoxB, cell cycle and neurogenesis
Sox genes encode for a group of transcription factors that share the presence of an HMG-type (high mobility group) box. This is a 79 amino acid motif that encodes their DNA binding domain. They were identified soon after the discovery of the mammalian testis-determining gene Sry, which also possesses an HMG box, and obtained their name from Sry (“Sox” Sry-related box genes). The members of the ...
متن کاملCell Cycle Regulation and Apoptosis1
Tissue homeostasis requires a balance between cell proliferation and death. Apoptosis and proliferation are linked by cell cycle regulators, and apoptotic stimuli affect both cell proliferation and death. Glucocorticoids induce G1 arrest and apoptosis in transformed lymphoid cells. Decreased expression of the cell cycle components c-myc and cyclin D3 is essential for glucocorticoid-induced grow...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2008
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0800029105